| Chemical Properties | Back Directory | [density ]
1.77±0.1 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml
DMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml | [form ]
Solid | [pka]
9.39±0.10(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C9H11FN2O6/c10-9(3-13)6(16)5(15)7(18-9)12-2-1-4(14)11-8(12)17/h1-2,5-7,13,15-16H,3H2,(H,11,14,17)/t5-,6+,7-,9-/m1/s1 | [InChIKey]
RDCYLPRXPILMRP-JVZYCSMKSA-N | [SMILES]
OC[C@@]1(F)O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O |
| Hazard Information | Back Directory | [Uses]
EIDD-2749 (4'-Fluorouridine) is an orally active RdRp inhibitor. EIDD-2749 effectively blocks the replication of RSV and SARS-CoV-2. EIDD-2749 also exhibits activity against HCV and lymphocytic choriomeningitis virus (LCMV). EIDD-2749 is a promising oral therapeutic candidate for COVID-19 and is also suitable for research on other RNA viruses[1][2][3]. | [in vivo]
EIDD-2749 (0.2, 1, 5 mg/kg; p.o.; single daily for 4 days) shows good orally efficacious in RSV infection mice model in a dose-dependent manner[1].
EIDD-2749 shows high efficacious to SARS-CoV-2 infection and is effective with a single daily dose versus molnupiravir administered twice daily in vivo[2]. | Animal Model: | Balb/cJ mice (RSV infection model)[1]. | | Dosage: | 0.2, 1, 5 mg/kg | | Administration: | Oral administration; single daily for 4 days | | Result: | Resulted in a statistically significant reduction in lung virus load. |
| [References]
[1] Sourimant J, et al. 4'-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication. Science. 2022 Jan 14;375(6577):161-167. DOI:10.1126/science.abj5508
[2] Abas AH, et al. 4’-fluorouridine and its derivatives as potential COVID-19 oral drugs: a review [version 1; peer review: 1 approved with reservations, 1 not approved]. F1000Research 2022, 11:410.
[3] George R. Painter, et al. 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto. Patent WO2019173602A1. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
|