| Identification | Back Directory | [Name]
2-METHYL-3-((2S)-PYRROLIDIN-2-YLMETHOXY)PYRIDINE | [CAS]
161417-03-4 | [Synonyms]
Abt-089
A 87089.0
Pozanicline
Unii-cl2002R563
ABT-089
(ABT089
2-Methyl-3-(2S-pyrrolidinylmethoxy)pyridine
(S)-3-(2-pyrrolidinylmethoxy)-2-picoline 2HCl
2-METHYL-3-((2S)-PYRROLIDIN-2-YLMETHOXY)PYRIDINE
Pyridine, 2-methyl-3-((2S)-2-pyrrolidinylmethoxy)-
Pyridine, 2-methyl-3-(2-pyrrolidinylmethoxy)-, (S)-
(S)-3-(2-pyrrolidinylmethoxy)-2-picoline dihydrochloride | [Molecular Formula]
C11H16N2O | [MDL Number]
MFCD11974724 | [MOL File]
161417-03-4.mol | [Molecular Weight]
192.26 |
| Chemical Properties | Back Directory | [Boiling point ]
302.7±22.0 °C(Predicted) | [density ]
1.046±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.99±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. | [References]
[1] Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. PMID:9336329
[2] Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8. DOI:10.1097/FBP.0000000000000111 |
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