| Identification | Back Directory | [Name]
Dibenzo[a,c]cycloocten-1-ol, 5,6,7,8-tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyl-, (6R,7S,12aR)- | [CAS]
1614245-13-4 | [Synonyms]
Dibenzo[a,c]cycloocten-1-ol, 5,6,7,8-tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyl-, (6R,7S,12aR)- | [Molecular Formula]
C23H30O6 | [MOL File]
1614245-13-4.mol | [Molecular Weight]
402.48 |
| Chemical Properties | Back Directory | [Boiling point ]
563.9±50.0 °C(predicted) | [density ]
1.118±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.96±0.60(predicted) |
| Hazard Information | Back Directory | [Uses]
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD)[1][2]. | [References]
[1] Hu D, et al. Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells. Phytochemistry. 2014 Aug;104:72-8. DOI:10.1016/j.phytochem.2014.04.014
[2] Jafernik K, et al. Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology. Chin Med. 2024 Jan 24;19(1):17. DOI:10.1186/s13020-024-00879-0 |
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