| Identification | Back Directory | [Name]
1-Piperidinepropanoic acid, 4-(8-fluoro[1]benzoxepino[4,3-b]pyridin-11(5H)-ylidene)- | [CAS]
161522-25-4 | [Synonyms]
FY609
FY-609
FY 609
1-Piperidinepropanoic acid, 4-(8-fluoro[1]benzoxepino[4,3-b]pyridin-11(5H)-ylidene)- | [Molecular Formula]
C21H21FN2O3 | [MOL File]
161522-25-4.mol | [Molecular Weight]
368.4 |
| Hazard Information | Back Directory | [Uses]
HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs[1][2]. | [IC 50]
H1 Receptor | [References]
[1] M Kakiuchi, et al. Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73(4):291-8. DOI:10.1254/jjp.73.291
[2] K Musoh, et al. Effect of a novel anti-allergic agent, HSR-609, on antigen-induced airway hyperresponsiveness in mice. Pharmacology. 2000 Aug;61(2):70-7. DOI:10.1159/000028383 |
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