| Identification | Back Directory | [Name]
VRT-1353385 | [CAS]
1616113-45-1 | [Synonyms]
EB8018
CS-1707
Sibofimloc
VRT-1353385
Antibiotic-202
VRT 1353385;VRT1353385
Antibiotic 202, Sibofimloc
Antibiotic-202, VRT-1353385
8,8'-(1'-Acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol]
D-glycero-D-manno-Oct-7-ynitol, 8,8'-(1'-acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-
1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone
1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone
1-(2,7-bis(((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)-1'l4-spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C35H39NO11 | [MOL File]
1616113-45-1.mol | [Molecular Weight]
649.68 |
| Hazard Information | Back Directory | [Uses]
Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2]. | [storage]
Store at -20°C | [References]
[1] Ramtohul, Yeeman K, et al. Preparation of mannose derivatives via coupling and click cycloaddition reactions for treating bacterial infections. From PCT Int. Appl. (2014), WO 2014100158 A1 20140626.
[2] W Reinisch, et al. P568 An open-label, multicenter, phase ib, pharmacokinetic (pk) and safety study of a fimh blocker, Sibofimloc (TAK-018/EB8018), in patients with Crohn’s disease (CD), Journal of Crohn's and Colitis, Volume 14, Issue Supplement_1, January 2020: S479–S480. |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
skychemical Co.Ltd
|
| Tel: |
021-20960837,QQ1332204249 |
| Website: |
http://www.skychemical.com |
|