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1616727-20-8

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1616727-20-8 Structure

1616727-20-8 Structure
IdentificationBack Directory
[Name]

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[(2-aminoethyl)amino]carbonyl]oxy]methyl]phenyl]-
[CAS]

1616727-20-8
[Synonyms]

MC-VC-PAB-NH2
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[[(2-aminoethyl)amino]carbonyl]oxy]methyl]phenyl]-
[Molecular Formula]

C31H46N8O8
[MDL Number]

MFCD34470248
[MOL File]

1616727-20-8.mol
[Molecular Weight]

658.75
Chemical PropertiesBack Directory
[Boiling point ]

995.7±65.0 °C(Predicted)
[density ]

1.275±0.06 g/cm3(Predicted)
[pka]

12.03±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

MC-VC-PAB-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Protease Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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