| Identification | Back Directory | [Name]
Methanesulfonamide, N-[1'-(6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl)-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]-, [R-(R*,R*)]- (9CI) | [CAS]
161799-18-4 | [Synonyms]
Methanesulfonamide, N-[1'-(6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl)-3,4-dihydro-4-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-6-yl]-, [R-(R*,R*)]- (9CI) | [Molecular Formula]
C25H29N3O4S | [MOL File]
161799-18-4.mol | [Molecular Weight]
467.58 |
| Hazard Information | Back Directory | [Uses]
L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1]. | [References]
[1] J S Mitcheson, et al. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000 Mar;115(3):229-40. DOI:10.1085/jgp.115.3.229
[2] S Vickers, et al. Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs. Drug Metab Dispos. 1998 May;26(5):388-95. PMID:9571219 |
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