| Identification | Back Directory | [Name]
Talampanel | [CAS]
161832-65-1 | [Synonyms]
C13670
CS-1843
Ampanel
Kinampa
AC1L4UWP
AC1Q5KPR
LY 300164
GYKI 53773
Talampanel
Talampanel (INN)
TalaMpanel(LY300164)
Talampanel (GYKI 53773)
Talampanel >=97% (HPLC)
AMPANEL; KINAMPA; TALAMPANEL (INN); GYKI 53773; AC1L4UWP; AC1Q5KPR
(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
(R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine
7H-1,3-Dioxolo[4,5-h][2,3]benzodiazepine, 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-, (8R)-
Talampanel
(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
(8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine Talampanel(LY300164) | [Molecular Formula]
C19H19N3O3 | [MDL Number]
MFCD00871406 | [MOL File]
161832-65-1.mol | [Molecular Weight]
337.37 |
| Chemical Properties | Back Directory | [Melting point ]
169-172° | [alpha ]
D -321.34° (c = 1 in methanol) | [Boiling point ]
528.9±60.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [pka]
4.67±0.10(Predicted) | [color ]
white to beige | [optical activity]
[α]/D -280 to -340°, c = 1 in methanol | [InChIKey]
JACAAXNEHGBPOQ-LLVKDONJSA-N |
| Hazard Information | Back Directory | [Uses]
Talampanel is a potent and selective AMPA antagonist and is also used as an antiepileptic drug. | [Definition]
ChEBI: Talampanel is a member of benzodioxoles. | [Biological Activity]
Talampanel ia a specific noncompetitive AMPA receptor antagonist and anticonvulsant. | [in vivo]
Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses[1]. | Animal Model: | Female mutant SOD1 Tg mice[1] | | Dosage: | 5 mg/kg | | Administration: | Orally administration; 5 mg/kg; once a day; 2 weeks | | Result: | Had a significant effect in reducing the calcium level only at the age of 12 weeks. |
| [storage]
+4°C |
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