| Identification | Back Directory | [Name]
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene | [CAS]
1618672-71-1 | [Synonyms]
NSC 636819
1,5-Bis[(E)-2-(3,4-dichlorophenyl)vinyl]-2,4-dinitrobenzene
1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
Benzene, 1,5-bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitro- | [Molecular Formula]
C22H12Cl4N2O4 | [MDL Number]
MFCD29081185 | [MOL File]
1618672-71-1.mol | [Molecular Weight]
510.15 |
| Chemical Properties | Back Directory | [Boiling point ]
625.5±55.0 °C(Predicted) | [density ]
1.558±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
NSC 636819 is a novel and selective KDM4A/KDM4B inhibitor that induces apoptosis in cultured prostate cancer cells. | [Biological Activity]
Cell permeable: yes''Primary Target
KDM4A/B''Reversible: yes | [in vivo]
NSC636819 (C-4) (20 or 40 mg/kg; ip; 5 times a week; 4 weeks) strongly suppresses A549 tumor growth and sensitizes tumors to TRAIL-inducer ONC201 in mouse model[2]. | Animal Model: | A549 Lung cancer xenograft model in mice[2] | | Dosage: | 20 mg/kg, 40 mg/kg | | Administration: | ip; 5 times per weeks, 27 days; with or without ONC201 (i.p.; 25?mg/kg, 1 time a week). | | Result: | Dose-dependently inhibited the tumor growth, and sensitized tumors to TRAIL.
Induced tumor expression of TRAIL, DR5 and the level of cleaved caspase-7 and H3K9me3, whereas decreased the expression of KDM4A in xenograft tumors.
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| [IC 50]
KDM4 | [storage]
Store at +4°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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