| Identification | Back Directory | [Name]
4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE | [CAS]
162012-70-6 | [Synonyms]
4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
4-chloro-6-nitro-7-fluoro-quinazoline
Quinazoline, 4-chloro-7-fluoro-6-nitro-
4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE###162012-70-6
Afatinib impurity 6: 4-chloro-7fluoro-6-nitroquinazoline | [EINECS(EC#)]
-0 | [Molecular Formula]
C8H3ClFN3O2 | [MDL Number]
MFCD08063159 | [MOL File]
162012-70-6.mol | [Molecular Weight]
227.58 |
| Chemical Properties | Back Directory | [Boiling point ]
395℃ | [density ]
1.649 | [Fp ]
193℃ | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [form ]
solid | [pka]
0.53±0.70(Predicted) | [InChI]
InChI=1S/C8H3ClFN3O2/c9-8-4-1-7(13(14)15)5(10)2-6(4)11-3-12-8/h1-3H | [InChIKey]
UYQMNEZWVKRWMS-UHFFFAOYSA-N | [SMILES]
N1=C2C(C=C([N+]([O-])=O)C(F)=C2)=C(Cl)N=C1 |
| Hazard Information | Back Directory | [Uses]
4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. |
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| Company Name: |
Shanghai Ennopharm Co., Ltd.
|
| Telephone: |
+86 (21) 6435-5022 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13640/0_EN.htm |
| Company Name: |
ChemShuttle, Inc.
|
| Telephone: |
0510-83588313-811 18800520310 |
| Website: |
www.jiehuapharma.com/ |
| Company Name: |
Alputon Inc.
|
| Telephone: |
021-60753308-14013 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13466/0_EN.htm |
|