| Identification | Back Directory | [Name]
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) | [CAS]
1620142-65-5 | [Synonyms]
R348
R-348
R 348
R-932348 choline
R932348 choline,R 932348 choline
Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]propanamide (1:1) | [Molecular Formula]
C28H35FN6O5S | [MOL File]
1620142-65-5.mol | [Molecular Weight]
586.68 |
| Hazard Information | Back Directory | [Uses]
R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1]. | [IC 50]
JAK3; IL-6; IL-10 | [References]
[1] Deuse T, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85(6):885-92. DOI:10.1097/TP.0b013e318166acc4 |
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