| Identification | Back Directory | [Name]
4-chloro-N-(6-pyrimidin-5-yloxypyrazin-2-yl)pyridine-2-carboxamide | [CAS]
1620203-63-5 | [Synonyms]
VU0431316
VU-0431316
VU 0431316
4-chloro-N-(6-pyrimidin-5-yloxypyrazin-2-yl)pyridine-2-carboxamide | [Molecular Formula]
C14H9ClN6O2 | [MDL Number]
MFCD28386185 | [MOL File]
1620203-63-5.mol | [Molecular Weight]
328.71 |
| Hazard Information | Back Directory | [Description]
VU0431316 is a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. | [Uses]
VU0431316 is a potent and selective non-competitive antagonist of mGlu5 with an IC50 value of 24 nM[1]. | [References]
[1] Brittney S Bates, et al. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3307-14. DOI:10.1016/j.bmcl.2014.06.003 |
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