| Identification | Back Directory | [Name]
DLK-IN-14 | [CAS]
1620574-24-4 | [Synonyms]
DLK-IN-1
DLK-IN-14
DLK IN 1,DLKIN1
DLK inhibitor 1
2-Pyridinamine, 5-[1-(1-methylethyl)-5-[(1α,5α,6α)-3-(3-oxetanyl)-3-azabicyclo[3.1.0]hex-6-yl]-1H-pyrazol-3-yl]-3-(trifluoromethoxy)- | [Molecular Formula]
C20H24F3N5O2 | [MOL File]
1620574-24-4.mol | [Molecular Weight]
423.44 |
| Chemical Properties | Back Directory | [Boiling point ]
502.0±50.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 62.5 mg/mL (147.60 mM) | [form ]
Solid | [pka]
8.25±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease. | [References]
[1] Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102. DOI:10.1021/acs.jmedchem.7b00843 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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