| Identification | Back Directory | [Name]
Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester | [CAS]
1620951-72-5 | [Synonyms]
PA-1
PA1 2HCl
Bis(3-methylsalicylic acid)1,1,3,3-tetrabutyl-1,3-distanna-2-oxapropane-1,3-diyl ester | [Molecular Formula]
C32H50O7Sn2 | [MOL File]
1620951-72-5.mol | [Molecular Weight]
784.155 |
| Hazard Information | Back Directory | [Uses]
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively[1]. | [References]
[1] Matthias Sch?nberger, et al. Controlling epithelial sodium channels with light using photoswitchable amilorides. Nat Chem. 2014 Aug;6(8):712-9. DOI:10.1038/nchem.2004 |
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