| Identification | Back Directory | [Name]
THZ1-R | [CAS]
1621523-07-6 | [Synonyms]
THZ1-R
N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[4-(dimethylamino)butanoylamino]benzamide
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]- | [Molecular Formula]
C31H30ClN7O2 | [MOL File]
1621523-07-6.mol | [Molecular Weight]
568.07 |
| Chemical Properties | Back Directory | [density ]
1.362±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
13.25±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. | [IC 50]
CDK7: 146 nM (IC50) | [References]
[1] Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. DOI:10.1038/nature13393 |
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