| Identification | Back Directory | [Name]
SPACE peptide | [CAS]
1621717-95-0 | [Synonyms]
SPACE peptide
SPACE peptide,AC-TGSTQHQ-CG,Disulfide Bridge 2–10 | [Molecular Formula]
C??H??N??O??S? | [MOL File]
1621717-95-0.mol | [Molecular Weight]
1090.15 |
| Chemical Properties | Back Directory | [Boiling point ]
1870.9±65.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
3.57±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ala-Cys-Thr-Gly-Ser-Thr-Gln-His-Gln-Cys-Gly (Disulfide bridge: Cys2-Cys10) |
| Hazard Information | Back Directory | [Uses]
SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid[1][2][3]. | [References]
[1] Chen M, et al. Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers. J Control Release. 2014 Jan 10;173:67-74. DOI:10.1016/j.jconrel.2013.10.007
[2] Hsu T, et al. Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15816-21. DOI:10.1073/pnas.1016152108
[3] Kumar S, et al. Peptides as skin penetration enhancers: mechanisms of action. J Control Release. 2015 Feb 10;199:168-78. DOI:10.1016/j.jconrel.2014.12.006 |
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