| Identification | Back Directory | [Name]
Radioprotectin-1 | [CAS]
1622006-09-0 | [Synonyms]
Radioprotectin-1
Benzoic acid, 5-chloro-2-[[[4-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)butyl]amino]sulfonyl]- | [Molecular Formula]
C23H19ClN2O6S | [MDL Number]
MFCD32062766 | [MOL File]
1622006-09-0.mol | [Molecular Weight]
486.92 |
| Chemical Properties | Back Directory | [Boiling point ]
720.6±70.0 °C(Predicted) | [density ]
1.490±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (256.72 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
2.69±0.36(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Radioprotectin-1 is a LPA2 receptor agonist. | [in vivo]
Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR [1].
Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) [1].
Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells[1].
| Animal Model: | 8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI) [1] | | Dosage: | 0.1 mg/kg, 0.3 mg/kg | | Administration: | Subcutaneous injection; every 12 hours; for 3 days | | Result: | Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS. |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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