| Identification | Back Directory | [Name]
((1R,3S)-1-AMINO-3-((R)-6-HEXYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPENTYL)METHANOL | [CAS]
1622180-31-7 | [Synonyms]
BMS-986104
((1R,3S)-1-AMINO-3-((R)-6-HEXYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPENTYL)METHANOL
Cyclopentanemethanol, 1-amino-3-[(6R)-6-hexyl-5,6,7,8-tetrahydro-2-naphthalenyl]-, (1R,3S)- | [Molecular Formula]
C22H35NO | [MDL Number]
MFCD30829539 | [MOL File]
1622180-31-7.mol | [Molecular Weight]
329.52 |
| Hazard Information | Back Directory | [Uses]
BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC)-induced demyelination in a three-dimensional brain cell culture assay. | [References]
[1] Yang MG, Xiao Z, Dhar TG, et al. Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator. J Med Chem. 2016;59(24):11138-11147. DOI:10.1021/acs.jmedchem.6b01433
[2] Dhar TG, Xiao HY, Xie J, et al. Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials. ACS Med Chem Lett. 2016;7(3):283-288. Published 2016 Jan 19. DOI:10.1021/acsmedchemlett.5b00448 |
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| Company Name: |
AstaTech, Inc
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| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
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