| Identification | Back Directory | [Name]
ONO-7579 | [CAS]
1622212-25-2 | [Synonyms]
ONO-7579
Urea, N-[2-[4-(2-amino-5-chloro-3-pyridinyl)phenoxy]-5-pyrimidinyl]-N'-[2-(methylsulfonyl)-5-(trifluoromethyl)phenyl]- | [Molecular Formula]
C24H18ClF3N6O4S | [MOL File]
1622212-25-2.mol | [Molecular Weight]
578.95 |
| Hazard Information | Back Directory | [Uses]
ONO-7579 is an orally active TRKA inhibitor that suppresses tumor growth by inhibiting the phosphorylation of TRKA. In colorectal cancer cells KM12, its EC50 is 17.6 ng/g (meaning that when each gram of tumor tissue contains 17.6 ng of ONO-7579, the activity of phosphorylated TRKA in the tumor is inhibited by 50%). ONO-7579 can be used in cancer research[1]. | [IC 50]
TrkA | [References]
[1] Iida H, et al. Pharmacokinetic-Pharmacodynamic-Efficacy Modeling of ONO-7579, a Novel Pan-Tropomyosin Receptor Kinase Inhibitor, in a Murine Xenograft Tumor Model. J Pharmacol Exp Ther. 2020 Jun;373(3):361-369. DOI:10.1124/jpet.119.264499 |
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