| Identification | Back Directory | [Name]
BRCA1-IN-2 | [CAS]
1622262-55-8 | [Synonyms]
BRCA1-IN-2
BRCA1 IN 2,BRCA1IN2,BRCA-1-IN-2
Glycinamide, N-[3-(1H-indol-3-yl)-1-oxopropyl]-O-phosphono-L-seryl-N-(4-phenylbutyl)- | [Molecular Formula]
C26H33N4O7P | [MDL Number]
MFCD30747867 | [MOL File]
1622262-55-8.mol | [Molecular Weight]
544.54 |
| Chemical Properties | Back Directory | [density ]
1.347±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
1.79±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions[1]. | [References]
[1] Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156. DOI:10.1007/978-1-4939-6584-7_10 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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