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16231-75-7

16231-75-7 Structure

16231-75-7 Structure
IdentificationBack Directory
[Name]

Atolide
[CAS]

16231-75-7
[Synonyms]

W 5733
Atolide
Go 1213
2-Amino-N-(4-diethylamino-2-methylphenyl)benzamide
Benzamide, 2-amino-N-[4-(diethylamino)-2-methylphenyl]-
[Molecular Formula]

C18H23N3O
[MDL Number]

MFCD00865324
[MOL File]

16231-75-7.mol
[Molecular Weight]

297.39
Chemical PropertiesBack Directory
[Melting point ]

153-154 °C
[Boiling point ]

415.7±45.0 °C(Predicted)
[density ]

1.153±0.06 g/cm3(Predicted)
[pka]

12.87±0.70(Predicted)
Hazard InformationBack Directory
[Originator]

Atolide,ZYF Pharm Chemical
[Uses]

Anticonvulsant.
[Manufacturing Process]

0.8 kg (4.5 moles) of freshly distilled 2-amino-5-diethylaminotoluene is mixed thoroughly with 0.75 kg (4.5 moles) of isatoic acid anhydride and the mixture heated to 100°C with stirring for three hours. The product formed is taken up before cooling in 2.5 liters of boiling ethyl acetate and the solution filtered. On cooling the filtrate 1.1 kg (83% of theory) of 2-amino-4'-(diethylamino)-2'- methylbenzanilide precipitates out. After re-crystallzation from n-propanol the colorless crystalline product obtained melts at 152°C.
[Therapeutic Function]

Anticonvulsant
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