| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Dichloromethane: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). | [storage]
Store at -20°C | [References]
1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and characterization J. Antibiot. (Tokyo) 48(2),113-118(1995). |
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