| Identification | Back Directory | [Name]
ML381(VU0488130) | [CAS]
1623481-80-0 | [Synonyms]
ML381
VU0488130
VU-0488130
VU 0488130
ML381(VU0488130)
ML381 (VU0488130) Fumarate
3-Isoxazolecarboxamide, 5-[(3-acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-(2-pyridinyl)ethyl]-
ML381(VU0488130) ?5-[(3-Acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide | [Molecular Formula]
C21H21N3O4 | [MDL Number]
MFCD34597614 | [MOL File]
1623481-80-0.mol | [Molecular Weight]
379.41 |
| Chemical Properties | Back Directory | [Boiling point ]
598.7±50.0 °C(Predicted) | [density ]
1.231±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
4.12±0.12(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC50 = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies[1][2]. | [in vivo]
ML381 (0.2 mg/kg; i.v.; single) possesses an overall acceptable DMPK profile for pharmacodynamic studies in rat, with the exception of poor metabolic stability and a potential for amide hydrolysis in plasma; as such, ML381 is best suited to use as an in vitro/electrophysiological probe[1]. | Animal Model: | Sprague-Dawley rat[1]. | | Dosage: | 0.2 mg/kg | | Administration: | Intravenous injection; single. | | Result: | 1.19Pharmacokinetic Parameters of ML381 in Sprague-Dawley rat[1].
| IV (0.2 mg/kg) | | Hepatic microsomal CLint (mL min-1 kg-1) | 770 | | Predicted CLhep (mL min-1 kg-1) | 64 | | fubrain | 0.14 | | Cbrain/Cplasma (Kp*) | 0.58 |
*Kp value was determined at 0.25 h following a 0.2 mg/kg IV dose (n=2).
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| [References]
[1] Gentry PR, et al. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82. DOI:10.1002/cmdc.201402051 |
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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