| Identification | Back Directory | [Name]
3-Pyridinecarboxylic acid, 1,2,6-tris(4-fluorophenyl)-4-[(4-fluorophenyl)amino]-1,2,5,6-tetrahydro-, ethyl ester | [CAS]
1624628-01-8 | [Synonyms]
3-Pyridinecarboxylic acid, 1,2,6-tris(4-fluorophenyl)-4-[(4-fluorophenyl)amino]-1,2,5,6-tetrahydro-, ethyl ester | [Molecular Formula]
C32H26F4N2O2 | [MOL File]
1624628-01-8.mol | [Molecular Weight]
546.56 |
| Chemical Properties | Back Directory | [Boiling point ]
636.1±55.0 °C(predicted) | [density ]
1.316±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
2.08±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
α-Glucosidase-IN-68 (Compound 2) is an inhibitor for α-Glucosidase, AChE, and BChE, with IC50 of 0.251, 0.774 and 0.793 μM, respectively. α-Glucosidase-IN-68 exhibits antioxidant efficacy, with IC50 of 0.69 μM and 0.02 μM, in DPPH and ABTS experiments. α-Glucosidase-IN-68 exhibits antidiabetic effect in Streptozotocin (HY-13753)-induced diabetic rat models[1]. | [IC 50]
α-Glucosidase: 0.251 μM (IC50); AChE: 0.774 μM (IC50); BChE: 0.793 μM (IC50) | [References]
[1] Mughal EU, et al., Exploring fluorine-substituted piperidines as potential therapeutics for diabetes mellitus and Alzheimer's diseases. Eur J Med Chem. 2024 Jul 5;273:116523. DOI:10.1016/j.ejmech.2024.116523 |
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