| Identification | Back Directory | [Name]
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone | [CAS]
16265-56-8 | [Synonyms]
6-Deoxyjacareubin
6-Desoxyjacareubin
6-Dehydroxyjacareubin
9-Deshydroxyjacareubin
5,10-dihydroxy-2,2-dimethylpyrano[3,2-b]xanthen-6-one
5,10-Dihydroxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one
J167.440D1,5-Dihydroxy-6',6'-dimethylpyrano[2',3':3,2]xanthone
2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,10-dihydroxy-2,2-dimethyl- | [Molecular Formula]
C18H14O5 | [MDL Number]
MFCD28009389 | [MOL File]
16265-56-8.mol | [Molecular Weight]
310.3 |
| Chemical Properties | Back Directory | [Melting point ]
214-215℃ | [Boiling point ]
523.4±50.0 °C(Predicted) | [density ]
1.410±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.59±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1]. | [Definition]
ChEBI: 6-Deoxyjacareubin is a member of pyranoxanthones. | [in vivo]
6-Deoxyjacareubin (5 mg/kg, i.p., every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. | Animal Model: | Male SOD1G93A mice (eight weeks)[1] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneally (i.p.), every seven days for 1 month | | Result: | Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss. |
| [References]
[1] Hoshino T, et al. 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res. 2021 Feb;163:43-51. DOI:10.1016/j.neures.2020.02.011 |
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