| Identification | Back Directory | [Name]
Elinafide | [CAS]
162706-37-8 | [Synonyms]
LU 79553
Elinafide
N,N'-(Trimethylenebis(iminoethylene))dinaphthalimide
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-[1,3-propanediylbis(imino-2,1-ethanediyl)]bis-
2-[2-[3-[2-(1,3-Dioxobenzo[e]isoindol-2-yl)ethylamino]propylamino]ethyl]benzo[e]isoindole-1,3-dione
2-[2-[3-[2-(1,3-dioxobenzo[de]isoquinolin-2-yl)ethylamino]propylamino]ethyl]benzo[de]isoquinoline-1,3-dione | [Molecular Formula]
C31H28N4O4 | [MOL File]
162706-37-8.mol | [Molecular Weight]
520.58 |
| Chemical Properties | Back Directory | [Melting point ]
160 °C | [Boiling point ]
750.7±55.0 °C(Predicted) | [density ]
1.344±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.69±0.19(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain.LU-79553 is a DNA-binding topoisomerase II inhibitor. The IC50 value of Elinafide for HT-29 cells is 0.014 μM[1][2]. | [References]
[1] Bra?a MF, et al. Naphthalimides as anti-cancer agents: synthesis and biological activity. Curr Med Chem Anticancer Agents. 2001;1(3):237-255. DOI:10.2174/1568011013354624
[2] J Gallego, et al. Solution structure and dynamics of a complex between DNA and the antitumor bisnaphthalimide LU-79553: intercalated ring flipping on the millisecond time scale. Biochemistry. 1999 Nov 16;38(46):15104-15. DOI:10.1021/bi9915869 |
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