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1627576-82-2

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1627576-82-2 Structure

1627576-82-2 Structure
IdentificationBack Directory
[Name]

1-Piperazineethanol, 4-[2-[[bis(4-fluorophenyl)methyl]sulfinyl]ethyl]-α-(phenylmethyl)-
[CAS]

1627576-82-2
[Synonyms]

1-Piperazineethanol, 4-[2-[[bis(4-fluorophenyl)methyl]sulfinyl]ethyl]-α-(phenylmethyl)-
[Molecular Formula]

C28H32F2N2O2S
[MOL File]

1627576-82-2.mol
[Molecular Weight]

498.63
Chemical PropertiesBack Directory
[Boiling point ]

680.9±55.0 °C(predicted)
[density ]

1.253±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

14.96±0.20(predicted)
Hazard InformationBack Directory
[Uses]

JJC8-088 is a potent inhibitor of DAT. JJC8-088 is a novel Modafinil-derived ligands. JJC8-088 can be used to study psychostimulant use disorders[1].
[in vivo]

JJC8-088 (3-30 mg/kg, i.p., 30/120 min) can effectively reduce the compulsive self-administration of methamphetamine in rats and increase the amount of exercise[1].
JJC8-088 (0-30 mg/kg, i.p., 30 min prior to testing) can cause a large and rapid increase in extracellular Dopamine (DA) (HY-B0451) levels in rats with history of Cocaine self-administration[2].

Animal Model:METH addict male Wistar rats (6-8 weeks old; weighing 200-250 g)[1]
Dosage:0/3/10/30 mg/kg
Administration:i.p.
Result:The half-life of JJC8-088 is 39 min.
Presented low levels in both brain and plasma.
[IC 50]

DAT: 2.53 nM (Ki)
[References]

[1] Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103.
[2] Newman AH, et al. Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444. DOI:10.1038/s41386-019-0366-z
1627576-82-2 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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