| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 16.67 mg/mL (47.44 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
6.41±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. | [storage]
Store at -20°C | [References]
[1] Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902. DOI:10.1021/acs.jmedchem.1c01026 |
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