| Identification | Back Directory | [Name]
4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) | [CAS]
162763-53-3 | [Synonyms]
A-86719.1
A 816719.1
A-816719.1
ABT-719 HCl
ABT-719 hydrochloride
ABT-719;ABT 719;ABT719;A-86719.1
4H-Quinolizine-3-carboxylicacid, 8-[(3S)-3-amino-1-pyrrolidinyl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-,hydrochloride (1:1) | [Molecular Formula]
C18H21ClFN3O3 | [MOL File]
162763-53-3.mol | [Molecular Weight]
381.83 |
| Hazard Information | Back Directory | [Description]
ABT-719 is a 2-pyridone antimicrobial with activity against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyelonephritis. Therapeutic ED50s for ABT-719 against these infections were equal to or up to ten-fold lower than those for ciprofloxacin, used as a reference because of similarity in mode of action. Against E. faecalis, the therapeutic ED50s for ABT-719 were 4.5-13.6 mg/kg.day for sc administration and 6.8-8.9 mg/kg.day for oral administration. ABT-719 was more potent than ciprofloxacin and vancomycin against the E. faecalis strains, which showed ciprofloxacin and vancomycin resistance covering a range of MICs. |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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