| Identification | Back Directory | [Name]
wu | [CAS]
1627929-55-8 | [Synonyms]
CS-2690
PLX51109
PXL51107
PLX51107
PXL 51107 ;PXL-51107
PLX51107;PLX 51107;PLX-51107
4-[6-(3,5-Dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]benzoic Acid
Benzoic acid, 4-[6-(3,5-dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]- | [Molecular Formula]
C26H22N4O3 | [MDL Number]
MFCD31657388 | [MOL File]
1627929-55-8.mol | [Molecular Weight]
438.48 |
| Chemical Properties | Back Directory | [Melting point ]
>270°C (dec.) | [Boiling point ]
683.3±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly, Heated) | [form ]
Solid | [pka]
3.68±0.10(Predicted) | [color ]
White to Off-White | [InChIKey]
AMSUHYUVOVCWTP-INIZCTEOSA-N | [SMILES]
C(O)(=O)C1=CC=C(C2C3=NC=C(C4=C(C)ON=C4C)C=C3N([C@H](C3=NC=CC=C3)C)C=2)C=C1 |
| Hazard Information | Back Directory | [Uses]
4-[6-(3,5-Dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]benzoic Acid, is a potent and selective BET inhibitor. | [in vivo]
PLX51107 (2 mg/kg, p.o.) inhibits splenomegaly by 75% in the Ba/F3 (murine IL3-dependent pro-B-cell line) splenomegaly mouse model, with the similar effect of 25 mg/kg OTX015. PLX51107 (20 mg/kg, qd, p.o.) exhibits potent antileukemic effects in disease models of aggressive chronic lymphocytic leukemia (CLL) and Richter transformation (RT) via oral administration once daily[1]. |
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