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1628287-16-0

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1628287-16-0 Structure

1628287-16-0 Structure
IdentificationBack Directory
[Name]

Pico145
[CAS]

1628287-16-0
[Synonyms]

HC-608
Pico145
1H-Purine-2,6-dione, 7-[(4-chlorophenyl)methyl]-3,7-dihydro-1-(3-hydroxypropyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]-
[Molecular Formula]

C23H20ClF3N4O5
[MDL Number]

MFCD31657331
[MOL File]

1628287-16-0.mol
[Molecular Weight]

524.88
Chemical PropertiesBack Directory
[Boiling point ]

666.9±65.0 °C(Predicted)
[density ]

1.48±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 125 mg/mL (238.15 mM)
[form ]

Solid
[pka]

14.85±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

Pico145, also known as HC-608, is a potent inhibitor of TRPC1/4/5 channels.
[Uses]

Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8[1].
[References]

[1] Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J Biol Chem. 2017 May 19;292(20):8158-8173. DOI:10.1074/jbc.M116.773556
Spectrum DetailBack Directory
[Spectrum Detail]

Pico145(1628287-16-0)1HNMR
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