| Identification | Back Directory | [Name]
Pico145 | [CAS]
1628287-16-0 | [Synonyms]
HC-608
Pico145
1H-Purine-2,6-dione, 7-[(4-chlorophenyl)methyl]-3,7-dihydro-1-(3-hydroxypropyl)-3-methyl-8-[3-(trifluoromethoxy)phenoxy]- | [Molecular Formula]
C23H20ClF3N4O5 | [MDL Number]
MFCD31657331 | [MOL File]
1628287-16-0.mol | [Molecular Weight]
524.88 |
| Chemical Properties | Back Directory | [Boiling point ]
666.9±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (238.15 mM) | [form ]
Solid | [pka]
14.85±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Pico145, also known as HC-608, is a potent inhibitor of TRPC1/4/5 channels. | [Uses]
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8[1]. | [References]
[1] Rubaiy HN, et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J Biol Chem. 2017 May 19;292(20):8158-8173. DOI:10.1074/jbc.M116.773556 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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