| Identification | Back Directory | [Name]
ARN 726
(ARN726) | [CAS]
1628343-77-0 | [Synonyms]
ARN 726
(ARN726)
ARN726 4-Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]-carbamate
Carbamic acid, N-[(3S)-2-oxo-3-azetidinyl]-, 4-cyclohexylbutyl ester | [Molecular Formula]
C14H24N2O3 | [MOL File]
1628343-77-0.mol | [Molecular Weight]
268.35 |
| Chemical Properties | Back Directory | [Boiling point ]
478.8±34.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 33 mg/ml; DMSO: 33 mg/ml; Ethanol: 33 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml | [form ]
A crystalline solid | [pka]
10.53±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 μM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2]. | [storage]
Store at -20°C | [References]
[1] Fotio Y, et al. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl). 2021 Jan;238(1):249-258. DOI:10.1007/s00213-020-05678-7
[2] Petracca R, et al. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. DOI:10.1039/c7cc06838g |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|