| Identification | Back Directory | [Name]
Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chloro-3-fluorophenoxy)- | [CAS]
1628478-15-8 | [Synonyms]
ISR-IN-1
trans-isrib A17
Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chloro-3-fluorophenoxy)-
N,N'-(trans-Cyclohexane-1,4-diyl)bis(2-(4-chloro-3-fluorophenoxy)acetamide)
N,N'-(trans-Cyclohexane-1,4-diyl)bis(2-(4-chloro-3-fluorophenoxy)acetamide) | [Molecular Formula]
C22H22Cl2F2N2O4 | [MOL File]
1628478-15-8.mol | [Molecular Weight]
487.32 |
| Chemical Properties | Back Directory | [Boiling point ]
705.1±60.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.44±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM)[1]. | [References]
[1] Hearn BR, et al. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19;11(8):870-80. DOI:10.1002/cmdc.201500483 |
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