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1628502-91-9

1628502-91-9 Structure

1628502-91-9 Structure
IdentificationBack Directory
[Name]

MW-150
[CAS]

1628502-91-9
[Synonyms]

MW-150
Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-
[Molecular Formula]

C24H23N5
[MDL Number]

MFCD32062790
[MOL File]

1628502-91-9.mol
[Molecular Weight]

381.47
Chemical PropertiesBack Directory
[Boiling point ]

606.1±55.0 °C(Predicted)
[density ]

1.202±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 40 mg/mL (104.86 mM; Need ultrasonic)
[form ]

A solid
[pka]

7.16±0.42(Predicted)
[color ]

Off-white to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H317-H335
[Precautionary statements ]

P261-P264-P271-P272-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P333+P313-P337+P313-P363-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

MW-150 (MW01-18-150SRM) is a selective, orally active, neurotransmitter p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the ability of endogenous p38α MAPK to phosphorylate the endogenous substrate MK2 in activated glia.
[Uses]

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
[Biological Activity]

MW-150 (MW01-18-150SRM) is a selective, orally active, neurotransmitter p38α MAPK inhibitor with a Ki of 101 nM. It inhibits the ability of endogenous p38α MAPK to phosphorylate the endogenous substrate MK2 in activated glia.
[in vivo]

MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].

Animal Model:APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1]
Dosage:2.5 mg/kg
Administration:Oral daily; 3-4 months (until cognitive impairment is present)
Result:Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
[target]

p38α

101 nM (Ki)

[IC 50]

p38α: 101 nM (Ki)
[storage]

Store at -20°C
[References]

[1] Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. DOI:10.1021/acschemneuro.5b00002
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