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1628641-89-3

1628641-89-3 Structure

1628641-89-3 Structure
IdentificationBack Directory
[Name]

GPR120 Agonist 4
[CAS]

1628641-89-3
[Synonyms]

GPR120 Agonist 4
[Molecular Formula]

C21H15ClF5NO3
[MOL File]

1628641-89-3.mol
[Molecular Weight]

459.79
Chemical PropertiesBack Directory
[Boiling point ]

532.5±50.0 °C(predicted)
[density ]

1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

4.54±0.10(predicted)
Hazard InformationBack Directory
[Uses]

GPR120 Agonist 4 (example 1) is a GPR120 agonist,with the EC50 values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus[1].
[in vivo]

GPR120 Agonist 4 (example 1) (0.2/0.3/1/3/10 mg/kg, i.p., 15/30/45/60/90 min) dose-dependently promotes a decrease in glucose levels of the high fat diet mice model[1].
GPR120 Agonist 4 (1/3/10 mg/kg, i.p., 15/30/45/60/90 min) inhibits the glucose level of starvation mouse model in a dose-dependent manner[1].

[IC 50]

GPR120: 1 μM (EC50)
[References]

[1] SUI, Zhihua, et al. Bicyclic pyrrole derivatives useful as agonists of gpr120. WO2015134038. 2014-03-07
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