| Identification | Back Directory | [Name]
Benzamide, N-[2-amino-5-(2-thienyl)phenyl]-4-[2-[4-(dimethylamino)phenyl]diazenyl]- | [CAS]
1628784-53-1 | [Synonyms]
BG48
BG-48
BG 48
Benzamide, N-[2-amino-5-(2-thienyl)phenyl]-4-[2-[4-(dimethylamino)phenyl]diazenyl]- | [Molecular Formula]
C25H23N5OS | [MOL File]
1628784-53-1.mol | [Molecular Weight]
441.55 |
| Hazard Information | Back Directory | [Description]
BG48 is a novel probe of chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light. | [Uses]
BG48 is a potent HDAC inhibitor. BG48 inhibits the enzymatic activity of HDAC1 and HDAC2[1]. | [IC 50]
HDAC1; HDAC2 | [References]
[1] Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. DOI:10.1038/nchembio.2042 |
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