| Identification | Back Directory | [Name]
19-Norpregnan-20-one, 3,21-dihydroxy-3-(trifluoromethyl)-, (3α,5β)- | [CAS]
162882-76-0 | [Synonyms]
GMA-839
19-Norpregnan-20-one, 3,21-dihydroxy-3-(trifluoromethyl)-, (3α,5β)- | [Molecular Formula]
C21H31F3O3 | [MOL File]
162882-76-0.mol | [Molecular Weight]
388.47 |
| Hazard Information | Back Directory | [Description]
GMA-839 is a selective modulator of gamma-aminobutyric acid(A) receptors. | [Uses]
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics[1]. | [References]
[1] Vanover KE, et al. Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. J Pharmacol Exp Ther. 2000 Oct;295(1):337-45. PMID:10991999 |
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