| Identification | Back Directory | [Name]
N4-([2,2-bipyridin]-3-yl)-N2-(3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,4-diamine | [CAS]
1628870-27-8 | [Synonyms]
TP-0184
itacnosertib
Itacnosertib(TP-0184)
N4-([2,2-bipyridin]-3-yl)-N2-(3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,4-diamine
2,4-Pyrimidinediamine, N4-[2,2'-bipyridin]-3-yl-N2-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]- | [Molecular Formula]
C26H28N8O | [MDL Number]
MFCD34578237 | [MOL File]
1628870-27-8.mol | [Molecular Weight]
468.55 |
| Chemical Properties | Back Directory | [Boiling point ]
701.3±70.0 °C(Predicted) | [density ]
1.276±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 12.5 mg/mL (26.68 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
7.76±0.42(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871[1]. | [IC 50]
JAK2; ACVR1; ALK5 | [storage]
Store at -20°C | [References]
[1] Mollard, Alexis; Warner, Steven L.; Flynn, Gary A.; Vankayalapati, Hariprasad; Bearss, David J. Preparation of [(piperazinylphenyl)amino]pyrimidine derivatives as JAK2 and ALK2 inhibitors. WO2014151871 A2 |
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