| Identification | Back Directory | [Name]
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide | [CAS]
1629615-99-1 | [Synonyms]
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide
3-Pyridinecarboxamide, 4-chloro-2-(cyclopropylmethoxy)-N-[(3-fluoro-4-methoxyphenyl)methyl]- | [Molecular Formula]
C18H18ClFN2O3 | [MOL File]
1629615-99-1.mol | [Molecular Weight]
364.8 |
| Hazard Information | Back Directory | [Uses]
ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice[1]. | [in vivo]
ALDH2 modulator 1 (compound 161) (10 mg/kg for i.v.; 40, 60 mg/kg for p.o.) reduces blood alcohol levels in mice treated with PO 5 g/kg of EtOH[1]. | Animal Model: | 8-9 weeks, 20-22 g, Male C57BL6 mice (treated with PO 5/kg of EtOH)[1] | | Dosage: | 40, 60 mg/kg for p.o. or 10 mg/kg for i.v. | | Administration: | P.o. or i.v. | | Result: | Reduced blood alcohol levels in mice treated with PO 5 g/kg of EtOH. |
| [IC 50]
ALDH2 | [References]
[1] Wenjin Yang, et al. Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. WO2014160185A2. |
|
|