| Identification | Back Directory | [Name]
(R)-DNMDP | [CAS]
1630760-60-9 | [Synonyms]
(R)-DNMDP
(R)DNMDP,(R) DNMDP
(R)-6-(4-(diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
3(2H)-Pyridazinone, 6-[4-(diethylamino)-3-nitrophenyl]-4,5-dihydro-5-methyl-, (5R)- | [Molecular Formula]
C15H20N4O3 | [MDL Number]
MFCD34469370 | [MOL File]
1630760-60-9.mol | [Molecular Weight]
304.34 |
| Hazard Information | Back Directory | [Uses]
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line[1][2]. | [References]
[1] de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. Nat Chem Biol. 2016 Feb;12(2):102-8. DOI:10.1038/nchembio.1984
[2] Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1. |
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