| Identification | Back Directory | [Name]
H-MET-GLU-VAL-GLY-TRP-TYR-ARG-PRO-PRO-PHE-SER-ARG-VAL-VAL-HIS-LEU-TYR-ARG-ASN-GLY-LYS-OH | [CAS]
163158-19-8 | [Synonyms]
MOG (35-55) (HUMAN)
H2N-MEVGWYRPPFSRVVHLYRNGK-OH
MYELIN OLIGODENDROCYTE GLYCOPROTEIN PRECURSOR
MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55) (HUMAN)
Myelin Oligodendrocyte Glycoprotein (35-55) (huMan)
MOG (35-55) (huMan)
H-MET-GLU-VAL-GLY-TRP-TYR-ARG-PRO-PRO-PHE-SER-ARG-VAL-VAL-HIS-LEU-TYR-ARG-ASN-GLY-LYS-OH
L-Lysine, L-methionyl-L-α-glutamyl-L-valylglycyl-L-tryptophyl-L-tyrosyl-L-arginyl-L-prolyl-L-prolyl-L-phenylalanyl-L-seryl-L-arginyl-L-valyl-L-valyl-L-histidyl-L-leucyl-L-tyrosyl-L-arginyl-L-asparaginylglycyl- | [Molecular Formula]
C120H179N35O28S | [MDL Number]
MFCD08274104 | [MOL File]
163158-19-8.mol | [Molecular Weight]
2591.99 |
| Hazard Information | Back Directory | [Uses]
MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide[1][2]. | [References]
[1] Cathleen Rich, et al. Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice. Eur J Immunol. 2004 May;34(5):1251-61. DOI:10.1002/eji.200324354
[2] Alfred R Oliver, et al.Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. J Immunol. 2003 Jul 1;171(1):462-8. DOI:10.4049/jimmunol.171.1.462 |
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