| Identification | Back Directory | [Name]
(-)-[3R,4S]-CHROMANOL 293B | [CAS]
163163-24-4 | [Synonyms]
(-)-[3R
4S]-Chromanol 293B
(-)-Chromanol 293B
(-)-[3R,4S]-Chromano
(-)-[3R,4S]-CHROMANOL 293B
(-)-[3R,4S]-Chromanol 293B
Chromanol 293B [3R,4S]-(-)-
( ) Chromanol 293B,()Chromanol 293B
N-[(3R,4S)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYLETHANESULFONAMIDE
Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl- | [Molecular Formula]
C15H20N2O4S | [MDL Number]
MFCD06798368 | [MOL File]
163163-24-4.mol | [Molecular Weight]
324.4 |
| Chemical Properties | Back Directory | [Melting point ]
192 °C | [Boiling point ]
474.1±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO: 18 mg/mL | [form ]
solid | [pka]
12.96±0.60(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
(-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic[1]. | [Definition]
ChEBI: Chromanol 293B is a 1-benzopyran. | [Biological Activity]
Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M). | [storage]
Store at RT | [References]
[1] Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962. PMID:10945846 |
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