| Identification | Back Directory | [Name]
Hydronidone | [CAS]
1631754-41-0 | [Synonyms]
Hydronidone
CD101 acetate
SP-3025 acetate
Biafungin acetate
Rezafungin acetate | [Molecular Formula]
C65H88N8O19 | [MDL Number]
MFCD32899863 | [MOL File]
1631754-41-0.mol | [Molecular Weight]
1285.44 |
| Hazard Information | Back Directory | [Uses]
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.[1][2]. | [in vivo]
Rezafungin acetate (Biafungin acetate) (1 mg/kg; i.p. once daily for 6 days) shows potent in vivo efficacy as prophylaxis against Pneumocystis in a mouse infection model[1]. | Animal Model: | C3H/HeN mice[1] | | Dosage: | 1 mg/kg | | Administration: | Intraperitoneal injection; once daily for 6 days | | Result: | Significantly reduced nuclei and asci burdens.
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| [References]
[1] Melanie Cushion, et al. Rezafungin Prophylactic Efficacy in a Mouse Model of Pneumocystis Pneumonia. VOLUME 25, ISSUE 3, SUPPLEMENT, S366, MARCH 01, 2019.
[2] Sofjan AK, et al. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 Sep;14:58-64. DOI:10.1016/j.jgar.2018.02.013 |
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