| Identification | Back Directory | [Name]
BI 689648 | [CAS]
1633009-87-6 | [Synonyms]
BI 689648
BI 689648
(BI-689648
6-[5-(methoxymethyl)pyridin-3-yl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide
1,8-Naphthyridine-1(2H)-carboxamide, 3,4-dihydro-6-[5-(methoxymethyl)-3-pyridinyl]- | [Molecular Formula]
C16H18N4O2 | [MDL Number]
MFCD28502113 | [MOL File]
1633009-87-6.mol | [Molecular Weight]
298.34 |
| Chemical Properties | Back Directory | [Boiling point ]
521.0±60.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 30 mg/mL (100.56 mM) | [form ]
Solid | [pka]
13.88±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively. | [in vivo]
After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of ~500 nM. For BI 689648 (aldosterone EC50=2 nM), appreciable changes in 11-DOC are only noted at plasma concentrations >2000 nM or >1000-fold its aldosterone EC50 while FAD286 shows a window of ~100-fold. BI 689648 exhibits minimal impact on 11-DC and only at very high plasma concentrations (~10 μM)[1]. | [IC 50]
CYP11 | [References]
[1] Weldon SM, et al. Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50. DOI:10.1124/jpet.116.236463 |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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