| Identification | Back Directory | [Name]
Phenol, 2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)- | [CAS]
1637741-58-2 | [Synonyms]
HSK3486
HSK-3486
HSK 3486
Cipepofol
Brincidofovir Impurity 37
Phenol, 2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)- | [Molecular Formula]
C14H20O | [MOL File]
1637741-58-2.mol | [Molecular Weight]
204.31 |
| Hazard Information | Back Directory | [Uses]
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis[1][2]. | [in vivo]
Cipepofol (Ciprofol; 100 μL; implanted into the abdomen of mice 1 h before ISO) suppresses ISO-induced myocardial damage, cardiac dysfunction, and inflammation and cardiomyocyte apoptosis[2].
| Animal Model: | Eighty male C57BL/6 mice (20-24 g, 8-10 weeks)[2] | | Dosage: | 100 μl | | Administration: | Implanted into the abdomen of mice 1 h before ISO | | Result: | Attenuated increased the content of serum CK-MB, LDH, and cTnT by ISO insults (100 mg/kg; sc; for 2 consecutive days to induce experimental myocardial infarction).
Significantly improved ISO-induced LV systolic and diastolic dysfunction.
Largely suppressed the increases in IL-6 IL-17 and TNF-α expression.
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| [References]
[1] Ming Lu, et al. Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia? Biomed Res Int. 2023 Jan 19:2023:7443226. DOI:10.1155/2023/7443226
[2] Yunzhao Yang, et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front Pharmacol. 2022 Nov 22:13:1037151. DOI:10.3389/fphar.2022.1037151 |
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