Identification | Back Directory | [Name]
Piroheptine | [CAS]
16378-22-6 | [Synonyms]
Trimol Piroheptine HCl piroheptine hydrochloride Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI) | [Molecular Formula]
C22H25N.ClH | [MDL Number]
MFCD01688069 | [MOL File]
16378-22-6.mol | [Molecular Weight]
339.907 |
Hazard Information | Back Directory | [Uses]
Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1]. | [Definition]
ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+). | [in vivo]
Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model[1]. Animal Model: | Male 8-week-old C57BL/6J mice (20-30 g)[1] | Dosage: | 20 mg/kg | Administration: | IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval) | Result: | Prevented loss of striatal dopamine. |
| [References]
[1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2 |
Safety Data | Back Directory | [Toxicity]
LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi) |
|
Company Name: |
LGM Pharma
|
Tel: |
1-(800)-881-8210 |
Website: |
www.lgmpharma.com |
|