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16378-22-6

16378-22-6 Structure

16378-22-6 Structure
IdentificationBack Directory
[Name]

Piroheptine
[CAS]

16378-22-6
[Synonyms]

Trimol
Piroheptine HCl
piroheptine hydrochloride
Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI)
[Molecular Formula]

C22H25N.ClH
[MDL Number]

MFCD01688069
[MOL File]

16378-22-6.mol
[Molecular Weight]

339.907
Chemical PropertiesBack Directory
[Melting point ]

250-253°
Hazard InformationBack Directory
[Uses]

Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1].
[Definition]

ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+).
[in vivo]

Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model[1].

Animal Model:Male 8-week-old C57BL/6J mice (20-30 g)[1]
Dosage:20 mg/kg
Administration:IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval)
Result:Prevented loss of striatal dopamine.
[References]

[1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2
Safety DataBack Directory
[Toxicity]

LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi)
16378-22-6 suppliers list
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Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
Company Name: Lanospharma Laboratories Co.,Ltd  
Tel: 13440048448
Website: www.lanospharma.com
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