| Identification | Back Directory | [Name]
Methanesulfonamide, N-[2-[5-[4-[(1R)-1-[(4,6-diamino-2-pyrimidinyl)thio]ethyl]-5-methyl-2-thiazolyl]-2-methoxyphenoxy]ethyl]- | [CAS]
1638148-50-1 | [Synonyms]
DI-82
Methanesulfonamide, N-[2-[5-[4-[(1R)-1-[(4,6-diamino-2-pyrimidinyl)thio]ethyl]-5-methyl-2-thiazolyl]-2-methoxyphenoxy]ethyl]- | [Molecular Formula]
C20H26N6O4S3 | [MOL File]
1638148-50-1.mol | [Molecular Weight]
510.65 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (195.83 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1]. | [References]
[1] Julian Nomme, et al. Structure-guided Development of Deoxycytidine Kinase Inhibitors With Nanomolar Affinity and Improved Metabolic Stability. J Med Chem. 2014 Nov 26;57(22):9480-94. DOI:10.1021/jm501124j
[2] Helena Almqvist, et al. CETSA Screening Identifies Known and Novel Thymidylate Synthase Inhibitors and Slow Intracellular Activation of 5-fluorouracil. Nat Commun. 2016 Mar 24;7:11040. DOI:10.1038/ncomms11040 |
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