| Identification | Back Directory | [Name]
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [CAS]
1638957-17-1 | [Synonyms]
ML395
ML-395
ML 395
VU0468809
VU-0468809
VU 0468809
2-Naphthalenecarboxamide, N-[2-[4-oxo-1-(3-pyridinylmethyl)-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]- | [Molecular Formula]
C26H29N5O2 | [MDL Number]
MFCD28502199 | [MOL File]
1638957-17-1.mol | [Molecular Weight]
443.54 |
| Chemical Properties | Back Directory | [Boiling point ]
757.5±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 50mg/mL | [form ]
solid | [pka]
14.55±0.46(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Description]
ML395, also known as VU0468809, is a potent PLD2 inhibitor. ML39 showed potent antiviral activity. ML395 (VU0468809), a potent, >80-fold PLD2 selective allosteric inhibitor (cellular PLD1, IC50 >30,000 nM; cellular PLD2, IC50 =360 nM). Moreover, ML395 possesses an attractive in vitro DMPK profile, improved physiochemical properties, ancillary pharmacology (Eurofins Panel) cleaner than any other reported PLD inhibitor, and has been found to possess interesting activity as an antiviral agent in cellular assays against a range of influenza strains (H1, H3, H5 and H7). | [Uses]
ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7)[1]. | [References]
[1] Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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