| Identification | Back Directory | [Name]
Propanamide, N-[4-[(3-bromo-1H-indol-5-yl)amino]-6-quinazolinyl]-3-chloro- | [CAS]
1639040-95-1 | [Synonyms]
pan-HER-IN-2
Propanamide, N-[4-[(3-bromo-1H-indol-5-yl)amino]-6-quinazolinyl]-3-chloro- | [Molecular Formula]
C19H15BrClN5O | [MOL File]
1639040-95-1.mol | [Molecular Weight]
444.71 |
| Chemical Properties | Back Directory | [Boiling point ]
725.5±60.0 °C(Predicted) | [density ]
1.674±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.75±0.43(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HER inhibitor with IC50 values of 0.72, 2.0, 8.2 and 75.1 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-2 induces apoptosis and shows antitumor activities[1]. | [IC 50]
EGFR: 0.72 nM (IC50); HER4: 2.0 nM (IC50); EGFR (L858R/T790M): 8.2 nM (IC50); HER2: 75.1 nM (IC50) | [References]
[1] Tang Q, et al. Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors. Eur J Med Chem. 2022 Apr 5;233:114249. DOI:10.1016/j.ejmech.2022.114249 |
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