| Identification | Back Directory | [Name]
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride | [CAS]
1639208-51-7 | [Synonyms]
Valbenazine dihydrochloride
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate dihydrochloride | [EINECS(EC#)]
948-534-1 | [Molecular Formula]
C24H40Cl2N2O4 | [MOL File]
1639208-51-7.mol | [Molecular Weight]
491.491 |
| Hazard Information | Back Directory | [Uses]
Valbenazine (NBI-98854) dihydrochloride is a VMAT2 inhibitor, used to treat tardive dyskinesia. Valbenazine dihydrochloride demonstrates potential benefit in alleviating symptoms associated with movement disorders resulting from chronic dopamine receptor blocking medications. Valbenazine dihydrochloride has been supported by evidence from preclinical models examining its role in the genetic factors linked to tardive dyskinesia. | [References]
[1] Genetics of tardive dyskinesia: Promising leads and ways forward DOI:10.1016/j.jns.2018.02.011 |
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